EClinicalMedicine · 2026
Considerations for epidemiological studies investigating emerging post-acute infection syndromes: Long Covid as a case study.
СтатьяОбзорНазвание и аннотация: Перевод в очереди
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Ayoubkhani Daniel, Atchison Christina J, Banerjee Amitava, Brightling Chris, Calvert Melanie, Diamond Ian, Eggo Rosalind M, Elliott Paul, Evans Rachael A, Haroon Shamil, Herrett Emily, Nafilyan Vahé, O'Mahoney Lauren L, Pinto Pereira Snehal M, Routen Ash, Shafran Roz, Stephenson Terence, Sterne Jonathan, Ward Helen, Zaccardi Francesco, Khunti Kamlesh
Аннотация
Epidemiological research studies into Long Covid, currently defined by prolonged symptoms after SARS-CoV-2 infection, have reported widely varying prevalence estimates. As well as rapidly evolving scientific knowledge of Long Covid, these differences are partly driven by substantial methodological heterogeneity between studies, including the outcome definition of Long Covid; duration of follow-up; study design, period and population; sampling frame; data source; and the statistical techniques employed. Having a robust understanding of the prevalence of and risk factors for Long Covid is essential for informing treatment pathways, service provision and policy decisions. In preparation for the public health response to future epidemics and pandemics, this review outlines key epidemiological and statistical considerations and recommendations when designing studies of emerging post-acute infection syndromes, focussing on Long Covid as a case study.