Isolated gastroschisis in successive siblings: a case report and review of the literature.

BACKGROUND

Although gastroschisis occurring in siblings is rare, a number of cases have been reported. A variety of inheritance patterns and embryologic explanations have previously been suggested. Young maternal age appears to be a consistent risk factor.

CASE: At age 17 years, Melanie (pseudonym) presented at 36 weeks' gestation and delivered a boy affected by gastroschisis. This condition had not been noted at a 13-week prenatal ultrasound. At age 18 years, Melanie delivered a second son with gastroschisis. There was no history of gastroschisis or other congenital anomaly in either parent's family. Melanie denied the use of alcohol, cigarettes, street drugs, and medications. She has since delivered 2 healthy children.

CONCLUSION

There is a need for preconception counselling for women who have experienced a pregnancy complicated by gastroschisis, to discuss the low but possible risk of recurrence. Early ultrasound may allow for detection or reassurance.