Granular cell tumor of the toe.

A 33-year-old black woman with an unusual case of a solitary granular cell tumor (GCT) involving the toe is presented, as is a review of the literature. The clinical presentation, histopathologic appearance, differential diagnosis, and treatment of solitary granular cell tumors are discussed. GCTs are uncommon tumors and are thought to be of Schwann cell origin. These tumors usually present as reddish-brown to flesh-colored papules that are occasionally tender or pruritic. The surface is usually smooth, but may be ulcerated or verrucous. Although they are usually solitary, they may be multiple. These tumors are almost always benign, but malignant variants have been reported. Predilection is greatest in females, and blacks are affected several times more often than whites. The skin overlying the face, trunk, fingers, and mucous membranes account for the vast majority of reported cases.