medRxiv : the preprint server for health sciences · 2025
Association of Adverse Prenatal Exposure Burden with Persistent Psychopathology and Accelerated Cortical Thinning in Youth.
СтатьяПрепринтНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Zhi Dongmei, Perdomo Sofia A, Arteaga Liam R, Hughes Dylan E, Dunn Erin C, Lee Phil H, Evins A Eden, Reeder Harrison T, Hadland Scott E, Doyle Alysa E, Clauss Jacqueline A, Sui Jing, Roffman Joshua L, Gilman Jodi M
Аннотация
IMPORTANCE: Adverse prenatal exposures (APEs) often co-occur and independently associate with risk for childhood psychopathology. Whether exposure to multiple APEs associates with persistent clinical effects through adolescence or underlying changes in brain maturation remains uncertain.
OBJECTIVE: To evaluate longitudinal associations among cumulative APE burden, risk for psychopathology, and age-related cortical thinning in adolescents.
DESIGN SETTING AND PARTICIPANTS: This cohort study analyzed 4-year follow-up data from the Adolescent Brain Cognitive Development (ABCD) Study, which enrolled 11,868 youth aged 9 to 10 years beginning in 2016. Sibling-comparison analysis was performed on 414 non-adopted sibling pairs with discordant APEs. Statistical analysis occurred from March to June 2025.
EXPOSURES: Cumulative APE burden was calculated by summing six binary prenatal exposures that independently associated with psychopathology at baseline: unplanned pregnancy; early maternal prenatal alcohol, tobacco, or marijuana use; complicated pregnancy; and complicated birth.
MAIN OUTCOMES AND MEASURES: Outcomes included annual Child Behavior Checklist (CBCL) scores of dimensional psychopathology, using both continuous and thresholded outcomes; and biennial cortical thickness measures from structural magnetic resonance imaging, analyzed using linear mixed-effects models.
RESULTS: Of 8,515 singleton children (4,055 females [47.6%]), 78% were exposed to at least one APE. Multiple APEs persistently and dose-dependently associated with increased odds of clinically significant psychopathology (CBCL total problems: odds ratio=2.01-6.75; corrected P=.0065-1.31×10-13). Associations of APEs with attention-deficit/hyperactivity disorder symptoms attenuated over time (interaction: F=13.51; corrected P=7.13×10-8), while those with depressive symptoms potentiated (interaction: F=5.82; corrected P=.0019). Greater APE burden associated with accelerated age-related cortical thinning in 36 of 68 cortical regions (interactions: F=3.26-8.89; corrected P's=0.039-4.86×10-4). Siblings with more exposures demonstrated persistently higher CBCL total problems (T=2.25; P=0.025) and accelerated cortical thinning (interactions: T=-3.00--2.10; P's<.05) in 5 of the 36 regions implicated in the larger sample.
CONCLUSIONS AND RELEVANCE: Multiple prenatal adversities associated with altered developmental trajectories of psychopathology and cortical maturation into mid-adolescence. These findings highlight the importance of fetal programming to mental health across life course, and the need for additional study of risk and resiliency-conferring factors in utero.
OBJECTIVE: To evaluate longitudinal associations among cumulative APE burden, risk for psychopathology, and age-related cortical thinning in adolescents.
DESIGN SETTING AND PARTICIPANTS: This cohort study analyzed 4-year follow-up data from the Adolescent Brain Cognitive Development (ABCD) Study, which enrolled 11,868 youth aged 9 to 10 years beginning in 2016. Sibling-comparison analysis was performed on 414 non-adopted sibling pairs with discordant APEs. Statistical analysis occurred from March to June 2025.
EXPOSURES: Cumulative APE burden was calculated by summing six binary prenatal exposures that independently associated with psychopathology at baseline: unplanned pregnancy; early maternal prenatal alcohol, tobacco, or marijuana use; complicated pregnancy; and complicated birth.
MAIN OUTCOMES AND MEASURES: Outcomes included annual Child Behavior Checklist (CBCL) scores of dimensional psychopathology, using both continuous and thresholded outcomes; and biennial cortical thickness measures from structural magnetic resonance imaging, analyzed using linear mixed-effects models.
RESULTS: Of 8,515 singleton children (4,055 females [47.6%]), 78% were exposed to at least one APE. Multiple APEs persistently and dose-dependently associated with increased odds of clinically significant psychopathology (CBCL total problems: odds ratio=2.01-6.75; corrected P=.0065-1.31×10-13). Associations of APEs with attention-deficit/hyperactivity disorder symptoms attenuated over time (interaction: F=13.51; corrected P=7.13×10-8), while those with depressive symptoms potentiated (interaction: F=5.82; corrected P=.0019). Greater APE burden associated with accelerated age-related cortical thinning in 36 of 68 cortical regions (interactions: F=3.26-8.89; corrected P's=0.039-4.86×10-4). Siblings with more exposures demonstrated persistently higher CBCL total problems (T=2.25; P=0.025) and accelerated cortical thinning (interactions: T=-3.00--2.10; P's<.05) in 5 of the 36 regions implicated in the larger sample.
CONCLUSIONS AND RELEVANCE: Multiple prenatal adversities associated with altered developmental trajectories of psychopathology and cortical maturation into mid-adolescence. These findings highlight the importance of fetal programming to mental health across life course, and the need for additional study of risk and resiliency-conferring factors in utero.