Three live-birth pregnancies in a woman with Williams syndrome.

OBJECTIVE

Maternal Williams syndrome with their associated (cardiac) malformations is rarely encountered during pregnancy.

METHODS

We report on a patient with Williams syndrome who has had 3 live-birth pregnancies.

RESULTS

Several noncardiac, mainly fetal, complications need to be anticipated: premature labor, intrauterine growth restriction with subsequent small-for-gestational-age offspring, and recurrence of congenital heart disease or similar syndromes.

CONCLUSION

The present case report illustrates that multiple live-birth pregnancies are possible in women with Williams syndrome, and it advocates the need for regular multidisciplinary assessments prior to and during pregnancy.