[Two new compounds from Cyclocarya paliurus fruits and their α-glucosidase inhibitory activity].

This study aims to isolate and identify the chemical constituents of Cyclocarya paliurus fruits. The constituents were isolated and purified by silica gel, Sephadex LH-20, and semi-preparative high performance liquid chromatography. Their structures were elucidated by a combination of IR, UV, HR-ESI-MS, NMR, and CD spectra. Four compounds(1-4) were successfully isolated from the 80% ethanol extract of the dried fruits, and they were identified as qingqianliulignanoside A(1), cyclopaloside E(2), emodin-8-O-β-D-glucoside(3), and daucosterol(4). Compounds 1 and 2 were new compounds, and compounds 3 was isolated from C. paliurus for the first time. The inhibitory activities of compounds 1-3 against α-glucosidase were assessed via the PNPG method. Compounds 2 exhibited certain α-glucosidase inhibitory activity, with the IC_(50) value of(148.3±11.4) μg·mL~(-1).