The effects of dexmedetomidine on biomarkers of oxidative stress and antioxidants in kidney.

BACKGROUND AND AIM: Cerebral ischemia not only disrupts brain functions, but also damages other organs. We aimed to determine whether two different doses of dexmedetomidine (DEX) had protective effects against the oxidative damage to kidneys.

MATERIALS AND

METHODS

Forty-two rats were equally divided into 7 groups. The first group was the control group. Second group members were operated to expose the cerebral artery without inducing cerebral ischemia. The third and fourth groups were DEX treatments groups. The fifth, sixth and seventh group were operated to induce cerebral ischemia. DEX was given to the groups at the 3rd, 24th and 48th hour.

RESULTS

MDA levels in the kidneys were higher in the group with cerebral ischemia. Significant reductions in MDA levels were observed after treatment with DEX in the ISCH group (p < 0.05). Decreased GSH-Px activity and reduced glutathione GSH levels in the kidneys were observed with DEX treatments. After treatment, there was a significant increase in α-tocopherol and β-carotene levels (p < 0.01).

CONCLUSION

DEX administration during cerebral ischemia had a positive effect on oxidative stress and antioxidants in rat kidney (Tab. 1, Fig. 5, Ref. 31).