Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
Correlation between novel checkmark-only headache diary and productivity loss and medication effectiveness in migraine patients.
СтатьяНаблюдательное исследованиеНазвание и аннотация: Перевод в очереди
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Yamamoto Shun, Tanei Takafumi, Oyama Shintaro, Ishizaki Tomotaka, Hashida Miki, Suzuki Takahiro, Hamasaki Hajime, Sakurai Takaaki, Mizuno Satomi, Wakabayashi Toshihiko, Saito Ryuta
Аннотация
BACKGROUND: Migraine reduces life quality and work productivity through absenteeism and presenteeism. However, existing paper-based headache diaries have limitations (time-consuming interpretation of heterogeneous entries, inadequate capture of work-related outcomes, etc.). We developed a calendar-style diary with checkmark-only entries to address these shortcomings, while maintaining simplicity for sustained patient adherence. In this single-center retrospective observational study, we assessed whether this format captures important information on patients with migraines attending a specialized headache clinic.
METHODS: The diary features five key elements: disability quantification (five levels: full-day absence to no productivity loss), headache occurrence time, headache intensity (severe vs. mild to moderate), acute medication intake with an effectiveness assessment, and migraine triggers. Simple diary-derived scores were created to assess absenteeism, presenteeism, headache intensity, and medication effectiveness. Correlation analyses were performed between these scores and validated questionnaires: Work Productivity and Activity Impairment (WPAI) and Migraine Assessment of Current Therapy (Migraine-ACT) for 7- and 31-d datasets, respectively.
RESULTS: After applying exclusion criteria, 222 and 188 participants were included in the 7- and 31-d datasets, respectively. Diary scores showed meaningful correlations with WPAI domains: absenteeism score with work absenteeism (Kendall's τ = 0.35), presenteeism score with presenteeism (Spearman's ρ = 0.41), overall work impairment (ρ = 0.41), and activity impairment (ρ = 0.36). The number of ineffective medications negatively correlated with the Migraine-ACT score (ρ = -0.27).
CONCLUSIONS: Our checkmark-only calendar diary systematically monitors productivity loss and treatment response in migraine patients, while maintaining patient adherence through its user-friendly design.
METHODS: The diary features five key elements: disability quantification (five levels: full-day absence to no productivity loss), headache occurrence time, headache intensity (severe vs. mild to moderate), acute medication intake with an effectiveness assessment, and migraine triggers. Simple diary-derived scores were created to assess absenteeism, presenteeism, headache intensity, and medication effectiveness. Correlation analyses were performed between these scores and validated questionnaires: Work Productivity and Activity Impairment (WPAI) and Migraine Assessment of Current Therapy (Migraine-ACT) for 7- and 31-d datasets, respectively.
RESULTS: After applying exclusion criteria, 222 and 188 participants were included in the 7- and 31-d datasets, respectively. Diary scores showed meaningful correlations with WPAI domains: absenteeism score with work absenteeism (Kendall's τ = 0.35), presenteeism score with presenteeism (Spearman's ρ = 0.41), overall work impairment (ρ = 0.41), and activity impairment (ρ = 0.36). The number of ineffective medications negatively correlated with the Migraine-ACT score (ρ = -0.27).
CONCLUSIONS: Our checkmark-only calendar diary systematically monitors productivity loss and treatment response in migraine patients, while maintaining patient adherence through its user-friendly design.