From the establishment of a national bioinformatics society to the development of a national bioinformatics infrastructure.

We describe the evolution of a bioinformatics national capacity from scattered professionals into a collaborative organisation, and advancements in the adoption of the bioinformatics infrastructure philosophy by the national community. The Romanian Society of Bioinformatics (RSBI), a national professional society, was founded in 2019 to accelerate the development of Romanian bioinformatics. Incrementally, RSBI expanded its role to include: i) developing a community and engaging the public and stakeholders, ii) a national training approach, including through increased interactions with European training resources, and iii) advocating national participation in European bioinformatics infrastructures. In a next step RSBI led the development of the national bioinformatics infrastructure, the Romanian Bioinformatics Cluster (CRB) with the mission to act as an ELIXIR National Node. In this paper we report both the successful projects in training, public engagement, and policy projects, as well as initiatives related to data federation that, while not successful, can serve as valuable learning experiences for future implementations. We explain CRB's structure and the role such an entity can play in the national bioinformatics infrastructure for data, tools, and training. Finally, we offer insights into the evolving role of the bioinformatics professional society and the synergies and interactions with the forthcoming National ELIXIR Node.