International journal of radiation biology · 1998
Chromosome aberration frequencies in human lymphocytes irradiated in a phantom by a mixed beam of fission neutrons and gamma-rays.
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Schmid E, Schraube H, Bauchinger M
Аннотация
PURPOSE: To provide further information on the existence of a significant quadratic component of the dose response relationship for the production of dicentrics in human lymphocytes by mixed fission neutron and gamma-ray irradiation, which has been observed previously employing the same beam under free-in-air conditions.
MATERIALS AND METHODS: Irradiation of blood samples and dosimetry was performed at 2 cm depth in a polymethyl methacrylate (PMMA) phantom of 16 cm side-length where the PMMA material fully surrounded the blood specimen. Chromosome analysis was carried out exclusively in complete first division metaphases.
RESULTS: Dicentric yields induced by absorbed doses between 0.043 and 2.68 Gy fit a linear-quadratic model with a quadratic coefficient significantly different from zero. The distribution of dicentrics is overdispersed compared to Poisson at lower doses, but is poissonian at higher doses.
CONCLUSION: The presence of a significant quadratic dose response coefficient for dicentrics, both for free-in-air and phantom irradiation, is caused by the various degraded fission spectra that produce neutrons or recoil protons over a broad energy range, rather than by the gamma-ray component of the beam.
MATERIALS AND METHODS: Irradiation of blood samples and dosimetry was performed at 2 cm depth in a polymethyl methacrylate (PMMA) phantom of 16 cm side-length where the PMMA material fully surrounded the blood specimen. Chromosome analysis was carried out exclusively in complete first division metaphases.
RESULTS: Dicentric yields induced by absorbed doses between 0.043 and 2.68 Gy fit a linear-quadratic model with a quadratic coefficient significantly different from zero. The distribution of dicentrics is overdispersed compared to Poisson at lower doses, but is poissonian at higher doses.
CONCLUSION: The presence of a significant quadratic dose response coefficient for dicentrics, both for free-in-air and phantom irradiation, is caused by the various degraded fission spectra that produce neutrons or recoil protons over a broad energy range, rather than by the gamma-ray component of the beam.