Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2026
Health-related quality of life in chronic kidney disease patients in low- and lower-middle income countries: a systematic review and meta-analysis.
СтатьяСистематический обзорМетаанализНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Muxunov Alimzhan, Almazan Joseph, Kalinina Dina, Kuanshaliyeva Zhanat, Gaipov Abduzhappar, Makhadiyeva Dinara, Kabibulatova Aida, Madikenova Meruyert, Nabiyev Altay, Sarria-Santamera Antonio
Аннотация
PURPOSE: Health-related quality of life (HRQoL) is a key outcome in chronic kidney disease (CKD), yet data from low- and lower-middle income countries (LLMICs) are underrepresented. The study systematically reviewed and meta-analyzed HRQoL among CKD patients in LLMICs by disease stage and treatment modality.
METHODS: Registered in PROSPERO (CRD420251016382), the review searched PubMed, Ovid MEDLINE, Scopus, and Web of Science (January 1, 2000 - March 28, 2025) for studies including adults with CKD stages 1-5, on dialysis, or post-transplant, using validated HRQoL instruments. Two reviewers independently screened studies, extracted data, and assessed quality using Joanna Briggs Institute tools. Pooled mean scores were estimated using random-effects meta-analysis, with meta-regression and Egger's test exploring heterogeneity and small-study effects.
RESULTS: A total of 123 studies (n = 24,007) from 22 countries were included. Pooled SF-36 scores were 42.8 (95% CI 39.4-46.3) for Physical Component Summary (PCS) and 47.7 (43.8-51.6) for Mental Component Summary (MCS) in early CKD, versus 36.9 (34.0-39.9) and 42.5 (38.9-46.1), respectively, in late CKD. Transplant recipients showed higher HRQoL than dialysis patients across WHOQOL-BREF domains. The EQ-5D index declined from 0.706 (0.589-0.823) in CKD 1-3 to 0.486 (0.357-0.614) in dialysis.
CONCLUSION: CKD patients in LLMICs experience substantial deterioration in quality of life, particularly at advanced stages. Compared to high-income settings, HRQoL scores in LLMICs remain markedly lower, revealing major global inequities. This first region-specific synthesis provides benchmarks for HRQoL across CKD stages and underscores the need for earlier intervention and broader access to transplantation.
METHODS: Registered in PROSPERO (CRD420251016382), the review searched PubMed, Ovid MEDLINE, Scopus, and Web of Science (January 1, 2000 - March 28, 2025) for studies including adults with CKD stages 1-5, on dialysis, or post-transplant, using validated HRQoL instruments. Two reviewers independently screened studies, extracted data, and assessed quality using Joanna Briggs Institute tools. Pooled mean scores were estimated using random-effects meta-analysis, with meta-regression and Egger's test exploring heterogeneity and small-study effects.
RESULTS: A total of 123 studies (n = 24,007) from 22 countries were included. Pooled SF-36 scores were 42.8 (95% CI 39.4-46.3) for Physical Component Summary (PCS) and 47.7 (43.8-51.6) for Mental Component Summary (MCS) in early CKD, versus 36.9 (34.0-39.9) and 42.5 (38.9-46.1), respectively, in late CKD. Transplant recipients showed higher HRQoL than dialysis patients across WHOQOL-BREF domains. The EQ-5D index declined from 0.706 (0.589-0.823) in CKD 1-3 to 0.486 (0.357-0.614) in dialysis.
CONCLUSION: CKD patients in LLMICs experience substantial deterioration in quality of life, particularly at advanced stages. Compared to high-income settings, HRQoL scores in LLMICs remain markedly lower, revealing major global inequities. This first region-specific synthesis provides benchmarks for HRQoL across CKD stages and underscores the need for earlier intervention and broader access to transplantation.