Der Urologe. Ausg. A · 2021
[Epithelioid angiomyolipoma of the kidney after successfully treated malignant melanoma].
Клинический случайСтатьяНазвание и аннотация: Перевод в очереди
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Rothe H, Gaber A, Dittrich B, Nagel M, Tuffaha M, Hoschke B
Аннотация
BACKGROUND: Therapy of epitheloid angiomyolipomas (eAML) may be challenging, since unlike classical angiomyolipomas this rare subclass of benign mesenchymal angiomyolipomas may present with lymph node metastases, local recurrent disease, and/or systemic metastatic disease in up to 30% of cases.
OBJECTIVES: We report here for the first time in Germany a case of eAML after successful treatment of malignant melanoma.
MATERIALS AND METHODS: Clinical and histological findings as well as results of the genetic analysis of the angiomyolipoma are presented.
RESULTS: A somatic, truncating mutation of the TSC2 gene was found in the angiomyolipoma.
CONCLUSION: The relationship to histologically similar tumor entities are presented and therapeutic options based on the genetic classification are discussed.
OBJECTIVES: We report here for the first time in Germany a case of eAML after successful treatment of malignant melanoma.
MATERIALS AND METHODS: Clinical and histological findings as well as results of the genetic analysis of the angiomyolipoma are presented.
RESULTS: A somatic, truncating mutation of the TSC2 gene was found in the angiomyolipoma.
CONCLUSION: The relationship to histologically similar tumor entities are presented and therapeutic options based on the genetic classification are discussed.