Psychotropic medication usage in sporadic versus genetic behavioral-variant frontotemporal dementia.
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Vargas-Gonzalez Juan-Camilo, Dimal Nico, Cortez Kasey, Heuer Hilary, Forsberg Leah K, Appleby Brian S, Barmada Sami, Bozoki Andrea, Clark David, Cobigo Yann, Darby R Ryan, Dickerson Bradford C, Domoto-Reilly Kimiko, Galasko Douglas R, Geschwind Daniel H, Ghoshal Nupur, Graff-Radford Neill R, Grant Ian M, Irwin David, Hsiung Ging-Yuek Robin, Honig Lawrence S, Kantarci Kejal, Léger Gabriel C, Litvan Irene, Mackenzie Ian R, Masdeu Joseph C, Mendez Mario F, Onyike Chiadi U, Pascual Belen, Pressman Peter, Ramos Eliana Marisa, Roberson Erik D, Rogalski Emily, Boeve Brad F, Boxer Adam L, Rosen Howie J, Tartaglia Maria Carmela, ALLFTD Consortium Investigators
Аннотация
METHODS: We analyzed data from sporadic and genetic bvFTD participants with PM prescriptions in the Advancing Research and Treatment in Frontotemporal Lobar Degeneration/Longitudinal Evaluation of Familial Frontotemporal Dementia Subjects study. We estimated ordinal odds ratio (OOR) of having more PM comparing sporadic and genetic bvFTD. Finally, we explored the neuropsychiatric symptom (NPS) combinations using classification and regression trees (CART).
RESULTS: We included 263 with sporadic and 193 with genetic bvFTD. The OOR for sporadic bvFTD to be on PM was 1.75 (95% confidence interval: 1.21 to 2.53) for the fully adjusted model. CART revealed the most common NPS combination was apathy + personality changes in 18% of participants.
DISCUSSION: Participants with sporadic bvFTD were twice as likely to be on PM compared to genetic bvFTD. The reason for increased PM usage in sporadic bvFTD participants should be further investigated.
HIGHLIGHTS: We report on patients with behavioral variant frontotemporal dementia (bvFTD). We evaluated the psychotropic medication (PM) prescription at baseline in the cohort. Patients with sporadic bvFTD had more prescriptions for PM than genetic patients. The frequency of symptoms combination was different in sporadic and genetic bvFTD.