Fertility and sterility · 2010
Ultrasound-guided high-intensity focused ultrasound ablation for adenomyosis: the clinical experience of a single center.
Клиническое исследованиеСтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Zhou Min, Chen Jin-Yun, Tang Liang-Dan, Chen Wen-Zhi, Wang Zhi-Biao
Аннотация
OBJECTIVE: To assess the midterm outcomes after ultrasound-guided high-intensity focused ultrasound (HIFU) ablation in treatment of patients with symptomatic adenomyosis.
DESIGN: A prospective clinical trial.
SETTING: University teaching hospital.
PATIENT(S): Seventy-eight patients with symptomatic adenomyosis.
INTERVENTION(S): A single treatment session of ultrasound-guided HIFU ablation for adenomyosis.
MAIN OUTCOME MEASURE(S): Dysmenorrhea and menorrhagia scores and the incidence of complications.
RESULT(S): In all 78 patients, 84.6% tolerated the treatment procedure well with pain scores between 0 and 4. Treatment was terminated in only one patient because of increased blood pressure persistently. Sixty-nine patients have finished at least an 18-month follow-up; the mean follow-up time was 24.2 months. Nonperfused regions in lesions were observed in 60 (87.0%) patients on the enhanced magnetic resonance imaging scans. Scores for menorrhea and dysmenorrhea decreased. Clinical effectiveness of the treatment was observed in 62 women (89.9%) with varying degrees of symptomatic relief of dysmenorrhea. Eight patients had relapses. Twenty-two patients (28.6%) had 27 complications. Of these, four had two or more complications. Twenty-three events (85.1%) did not need medical intervention (Society of Interventional Radiology class A). No serious complications including death or major permanent injuries were observed.
CONCLUSION(S): Ultrasound-guided HIFU ablation may be a safe and effective noninvasive alternative in the treatment of symptomatic adenomyosis.
DESIGN: A prospective clinical trial.
SETTING: University teaching hospital.
PATIENT(S): Seventy-eight patients with symptomatic adenomyosis.
INTERVENTION(S): A single treatment session of ultrasound-guided HIFU ablation for adenomyosis.
MAIN OUTCOME MEASURE(S): Dysmenorrhea and menorrhagia scores and the incidence of complications.
RESULT(S): In all 78 patients, 84.6% tolerated the treatment procedure well with pain scores between 0 and 4. Treatment was terminated in only one patient because of increased blood pressure persistently. Sixty-nine patients have finished at least an 18-month follow-up; the mean follow-up time was 24.2 months. Nonperfused regions in lesions were observed in 60 (87.0%) patients on the enhanced magnetic resonance imaging scans. Scores for menorrhea and dysmenorrhea decreased. Clinical effectiveness of the treatment was observed in 62 women (89.9%) with varying degrees of symptomatic relief of dysmenorrhea. Eight patients had relapses. Twenty-two patients (28.6%) had 27 complications. Of these, four had two or more complications. Twenty-three events (85.1%) did not need medical intervention (Society of Interventional Radiology class A). No serious complications including death or major permanent injuries were observed.
CONCLUSION(S): Ultrasound-guided HIFU ablation may be a safe and effective noninvasive alternative in the treatment of symptomatic adenomyosis.