Dinickel-Catalyzed Asymmetric Allylic Alkylation of Cyclic Ketones with Allylic Amine Derivatives.

A dinickel-catalyzed direct asymmetric allylic alkylation of benzocyclic ketones has been developed. This method enables the efficient transformation of various α-alkyl benzocyclohexanones and benzocyclopentanones with allylic sulfonamides, affording chiral ketones bearing α-quaternary carbon stereocenters in high yields and with excellent enantioselectivities.