Determination of thio compounds in urine of workers exposed to carbon disulfide.

Metabolites of carbon disulfide excreted into the urine of viscose workers are detectable by application of a nonselective assay for the determination of thio compounds. Enhanced secretion of thio compounds occurred especially at the end of the workday in exposed workers. A classification of urine samples according to the degree of exposure gave evidence for a relation between exposure to carbon disulfide and excretion of thio compounds in urine. The presence of 2-thiothiazolidine-4-carboxylic acid in urine of viscose workers was indicated by TLC, UV-spectrometry, and HPLC.