Further studies of trans-sobrerol metabolism: rat, dog and human urine.

The urinary metabolites of d, l-trans-sobrerol were investigated after oral administration to rats, dogs and humans. Structural analysis of the urinary metabolites indicates that allylic hydroxylation, oxidation and glucuronylation are the common interspecies modes of trans-sobrerol biotransformation. Comparison of the findings of trans-sobrerol with previous investigations of cyclic monoterpenes shows similarities in their metabolism in vivo, including the resistance to oxidation of the cyclic trisubstituted double bond.