To escape or not to escape, that is the question.

Marco et al. (https://doi.org/10.1083/jcb.202507217) identify a tumor-selective endocytic route in which CD44 and EPHA2 co-traffic antisense oligonucleotides (ASOs) to nuclear-proximal, recycling-endosome-like compartments that become leaky through lipid peroxidation and show that stress granule-mediated repair of these compartments limits productive ASO escape.