Anti-inflammatory triterpenoids from dammar resin of Vatica mangachapoi.

Five previously undescribed triterpenoids (1-5), and four triterpenoids (6-9) which had been synthesized previously but had not been isolated from a natural source, along with twenty-three known triterpenoids (10-32) were isolated from the methanol extract of dammar resin of Vatica mangachapoi. HRESIMS, NMR, UV, and ECD spectroscopy were employed to determine the structures of these triterpenoids. Compounds 2, 6, 22, and 29 significantly reduced LPS-induced TNF-α levels in RAW264.7 cells, while compounds 3, 13, 16, and 17 reduced IL-6 levels at a concentration of 10 μM. These results suggest that these compounds exhibit potential anti-inflammatory activity.