[Radioimmunodetection in the diagnosis of trophoblastic disease].

OBJECTIVE

To study the efficiency of radioimmunodetection (RID) to locate the loci of trophoblastic disease.

METHOD: 24 RIDs were performed with 131I labeled mouse anti-hCG monoclonal antibodies on 21 patients with trophoblastic disease.

RESULTS

Of 24 RIDs performed, 13 were positive, including one false positive; 11 were negative, including two false negative. The sensitivity of RID was 85.7%, the specificity was 90.0%, the accuracy was 87.5%. In 8 patients who underwent operations after RID, the findings of RID were in accordance with the pathologic and immunohistologic findings.

CONCLUSIONS

RID is an efficient imaging method for trophoblastic disease. In some cases, RID showed its value as a functional diagnostic method.