International journal of fertility and menopausal studies · 1996
The successful use of hyperstimulated washed therapeutic donor insemination after standard therapeutic donor insemination has failed.
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Dow M P, Jones J M, Dumesic D A, Lu Y, Shapiro S S
Аннотация
OBJECTIVE: To investigate whether an aggressive therapeutic donor insemination regimen (stimulated folliculogenesis and ovulation plus intrauterine insemination) can produce a better fecundability rate than a more traditional insemination regimen (non-stimulated folliculogenesis plus LH-timed intracervical insemination) in women who have failed to become pregnant during an initial series of six traditional insemination cycles.
DESIGN: A retrospective comparison of fecundability rates was undertaken between women undergoing the traditional insemination protocol and those who voluntarily switched to ovarian hyperstimulation coupled with intrauterine insemination.
PARTICIPANTS: Eight-two women who failed to become pregnant during an initial series of six intracervical insemination cycles.
RESULTS: Fecundability was 5.6% in cycles of continued urinary LH-timed intracervical insemination and 19.4% when the more aggressive regimen was applied. The difference in fecundability between protocols was significant (P < .005).
CONCLUSION: After an initial series of donor inseminations has failed, a more aggressive insemination regimen involving ovarian hyperstimulation followed by washed intrauterine insemination provides a higher fecundability rate than continued intracervical insemination.
DESIGN: A retrospective comparison of fecundability rates was undertaken between women undergoing the traditional insemination protocol and those who voluntarily switched to ovarian hyperstimulation coupled with intrauterine insemination.
PARTICIPANTS: Eight-two women who failed to become pregnant during an initial series of six intracervical insemination cycles.
RESULTS: Fecundability was 5.6% in cycles of continued urinary LH-timed intracervical insemination and 19.4% when the more aggressive regimen was applied. The difference in fecundability between protocols was significant (P < .005).
CONCLUSION: After an initial series of donor inseminations has failed, a more aggressive insemination regimen involving ovarian hyperstimulation followed by washed intrauterine insemination provides a higher fecundability rate than continued intracervical insemination.