The Journal of emergency medicine · 2024
Is Phenobarbital an Effective Treatment for Alcohol Withdrawal Syndrome?
СтатьяОбзорНазвание и аннотация: Перевод в очереди
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Long Brit, Keim Samuel M, Gottlieb Michael, Rathlev Niels
Аннотация
BACKGROUND: Alcohol use disorder is associated with a variety of complications, including alcohol withdrawal syndrome (AWS), which may occur in those who decrease or stop alcohol consumption suddenly. AWS is associated with a range of signs and symptoms, which are most commonly treated with GABAergic medications.
CLINICAL QUESTION: Is phenobarbital an effective treatment for AWS?
EVIDENCE REVIEW: Studies retrieved included two prospective, randomized, double-blind studies and three systematic reviews. These studies provided estimates of the effectiveness and safety of phenobarbital for treatment of AWS.
CONCLUSIONS: Based on the available literature, phenobarbital is reasonable to consider for treatment of AWS. Clinicians must consider the individual patient, clinical situation, and comorbidities when selecting a medication for treatment of AWS.
CLINICAL QUESTION: Is phenobarbital an effective treatment for AWS?
EVIDENCE REVIEW: Studies retrieved included two prospective, randomized, double-blind studies and three systematic reviews. These studies provided estimates of the effectiveness and safety of phenobarbital for treatment of AWS.
CONCLUSIONS: Based on the available literature, phenobarbital is reasonable to consider for treatment of AWS. Clinicians must consider the individual patient, clinical situation, and comorbidities when selecting a medication for treatment of AWS.