Multimodal treatment approach for giant condylomata acuminata complicated by lichen sclerosus: A case report.

A 65-year-old male presented with cauliflower-like growths on the penis for two years. Physical examination revealed erythema and cutaneous atrophy on the prepuce, glans, and external urethral meatus, with diffuse cauliflower-like proliferations on this basis. Based on the clinical and histopathological findings, a diagnosis of condylomata acuminata (CA) with concomitant lichen sclerosus (LS) was made. The patient received a multimodal treatment involving 5-aminolevulinic acid photodynamic therapy (ALA-PDT), Holmium-laser, and curettage, which led to significant improvement of the lesions. No recurrence was observed during a 4-year follow-up period.