Intense FDG Uptake in Penile Condyloma Acuminatum Mimicking Malignancy in a Melanoma Patient.

A 71-year-old man with newly diagnosed plantar melanoma underwent 18 F-FDG PET/CT for staging. In addition to the hypermetabolic primary lesion, intense FDG uptake was observed at the left penile shaft (SUVmax 14.3), raising suspicion for metastatic disease or primary penile malignancy. Physical examination revealed a papillomatous lesion suggestive of condyloma acuminatum. Histopathologic analysis following biopsy confirmed condyloma. This case highlights that condyloma acuminatum can present with intense FDG uptake and may mimic malignancy. Awareness of this potential false-positive finding is essential to avoid misdiagnosis and overtreatment in oncology patients.