Movement disorders clinical practice · 2026
Surgical Intervention for Posthyperglycemic Hemiballismus: Illustrative Case and Literature Review.
СтатьяОбзорНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Mani Racheed, Kim Tiffany, Kim Thomas, Uwakwe Chiemeka, Zheng Camelia Yuejiao, Mofakham Sima, James Eltonnelle, Mikell Charles, Schwartz Guy
Аннотация
BACKGROUND: Hemiballismus/hemichorea can manifest as a systemic sequala of severe hyperglycemia. This typically resolves with optimal glycemic control supplemented by neuroleptic agents. However, in a subset of patients, this hyperkinetic movement disorder may persist despite maximal medical management.
CASES: We present a 70-year-old man with type 2 diabetes mellitus (DM) who presented with 6 months of right-sided hemiballismus/hemichorea that started after a previous episode of nonketotic hyperglycemia. Despite optimal glucose control and the administration of several neuroleptic agents, his symptoms failed to resolve. He underwent left-sided deep brain stimulation (DBS) to the globus pallidus internus (GPi), with subsequent improvement in his hyperkinetic movements.
LITERATURE REVIEW: We document 7 cases in the literature of posthyperglycemic chorea-ballism (PHGCB) treated with either pallidal or thalamic DBS or pallidotomy. The procedures were safe and well tolerated, and all patients demonstrated clinical improvement following surgery.
CONCLUSION: PHGCB represents a rare but serious complication of DM. There is a subset of patients who fail to respond to maximal medical therapy. Our illustrative case and review demonstrate that these patients may benefit from neurosurgical intervention. Further studies with long-term follow-up are warranted to substantiate the value of surgical approaches for medically refractory diabetic striatopathy.
CASES: We present a 70-year-old man with type 2 diabetes mellitus (DM) who presented with 6 months of right-sided hemiballismus/hemichorea that started after a previous episode of nonketotic hyperglycemia. Despite optimal glucose control and the administration of several neuroleptic agents, his symptoms failed to resolve. He underwent left-sided deep brain stimulation (DBS) to the globus pallidus internus (GPi), with subsequent improvement in his hyperkinetic movements.
LITERATURE REVIEW: We document 7 cases in the literature of posthyperglycemic chorea-ballism (PHGCB) treated with either pallidal or thalamic DBS or pallidotomy. The procedures were safe and well tolerated, and all patients demonstrated clinical improvement following surgery.
CONCLUSION: PHGCB represents a rare but serious complication of DM. There is a subset of patients who fail to respond to maximal medical therapy. Our illustrative case and review demonstrate that these patients may benefit from neurosurgical intervention. Further studies with long-term follow-up are warranted to substantiate the value of surgical approaches for medically refractory diabetic striatopathy.