Treatment of sexual disorders in people with epilepsy.

Sexual dysfunction is underreported in persons with epilepsy. The evaluation of sexual physiology in small samples of epilepsy patients shows abnormal sexual functioning, and points to low free testosterone levels as a contributing factor. Abnormal sexual physiology in epilepsy patients may be due to antiseizure medication-related altered testosterone metabolism and abnormal central gonadotropin secretion due to epileptic physiology in the brain. More information exists on the sexual side effects of "classic" antiseizure medications than the "new generation" of antiseizure medications; barbiturates appear to have the greatest risk. More active surveying for sexual dysfunction should be undertaken in epilepsy clinics; a simple, self-reported scale of sexual functioning is available. Testosterone replacement for men, dehydroepiandrosterone for women, and sildenafil for restoring sexual performance are appropriate.