Neurodegenerative disease management · 2026
Pilot randomized controlled trial of the ReFresh online fatigue management programme for people with Parkinson's disease.
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Alageel Sarah, Hibberd Jane, Deane Katherine H O
Аннотация
AIMS: Fatigue is one of the most disabling symptoms experienced by people with Parkinson's disease, yet few evidence-based non-pharmacological interventions are available. This study evaluated the feasibility, acceptability, and exploratory clinical signals of the Rebalancing Fatigue and Enhancing Self-Help (ReFresh) online fatigue management programme for people with Parkinson's disease.
PATIENTS AND METHODS: A pilot randomized controlled trial with a wait-list control group was conducted. Participants with Parkinson's disease experiencing fatigue were randomized to either the six-week ReFresh online programme or a wait-list control. Feasibility outcomes included recruitment, retention, adherence, and participant engagement. Secondary outcomes included fatigue severity, fatigue self-efficacy, sleep quality, mood, and occupational performance.
RESULTS: A total of 118 participants were randomized. Recruitment targets were achieved; however, retention and adherence were modest. Participants who completed the programme reported improvements in fatigue self-efficacy and perceived ability to manage fatigue, while changes in fatigue severity were smaller. Qualitative feedback indicated that participants valued the flexibility and accessibility of the online format.
CONCLUSIONS: The ReFresh programme demonstrated feasibility and acceptability as a digitally delivered fatigue management intervention for people with Parkinson's disease. Future research should explore strategies to improve engagement and evaluate the programme in a fully powered randomized controlled trial.
CLINICAL TRIAL REGISTRATION: ISRCTN Registry, ISRCTN62114944, https://www.isrctn.com/ISRCTN62114944.
PATIENTS AND METHODS: A pilot randomized controlled trial with a wait-list control group was conducted. Participants with Parkinson's disease experiencing fatigue were randomized to either the six-week ReFresh online programme or a wait-list control. Feasibility outcomes included recruitment, retention, adherence, and participant engagement. Secondary outcomes included fatigue severity, fatigue self-efficacy, sleep quality, mood, and occupational performance.
RESULTS: A total of 118 participants were randomized. Recruitment targets were achieved; however, retention and adherence were modest. Participants who completed the programme reported improvements in fatigue self-efficacy and perceived ability to manage fatigue, while changes in fatigue severity were smaller. Qualitative feedback indicated that participants valued the flexibility and accessibility of the online format.
CONCLUSIONS: The ReFresh programme demonstrated feasibility and acceptability as a digitally delivered fatigue management intervention for people with Parkinson's disease. Future research should explore strategies to improve engagement and evaluate the programme in a fully powered randomized controlled trial.
CLINICAL TRIAL REGISTRATION: ISRCTN Registry, ISRCTN62114944, https://www.isrctn.com/ISRCTN62114944.