Fa yi xue za zhi · 2024
Structure Confirmation of Three New Psychoactive Substances and Qualitative Identification of Unknown Substances.
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Nie Zong-Yang, Hu Wei, Li Ling-Yu, Zhang Qing-Bo, Huang Xin, Li Bo
Аннотация
OBJECTIVES: To establish the structural confirmation methods of three suspected new psychoactive substances (NPSs), and explore a more general qualitative testing method.
METHODS: Infrared absorption spectroscopy (IR), gas chromatography-mass spectrometry (GC-MS), 1H-nuclear magnetic resonance spectroscopy (1H-NMR), 13C-nuclear magnetic resonance spectroscopy (13C-NMR), 19F-nuclear magnetic resonance spectroscopy (19F-NMR) and other techniques were used to identify the composition and structure of 5 samples containing suspected NPS submitted by public security bureaus.
RESULTS: NPSs were found in the above 5 samples, and 3 were confirmed as NPS included in the newly listed controlled substances on July 1, 2024, namely 2-(methylamino)-2-(2-methylphenyl)cyclohexan-1-one (2-MDCK), 2-(ethylamino)-2-(2-fluorophenyl)cyclohexan-l-one (2-FXE), 1-(3,4-methylenedioxyphenyl)-2-(dimethylamino)pentan-1-one (dipentylone), respectively. The first two substances were phencyclidine NPS, and the third substance was synthetic cathinone NPS.
CONCLUSIONS: This study systematically summarizes the distinguishing features of the infrared absorption spectrometry, nuclear magnetic resonance spectroscopy and mass spectrometry of three NPSs, which can provide a reference for the qualitative identification of unknown substances.
METHODS: Infrared absorption spectroscopy (IR), gas chromatography-mass spectrometry (GC-MS), 1H-nuclear magnetic resonance spectroscopy (1H-NMR), 13C-nuclear magnetic resonance spectroscopy (13C-NMR), 19F-nuclear magnetic resonance spectroscopy (19F-NMR) and other techniques were used to identify the composition and structure of 5 samples containing suspected NPS submitted by public security bureaus.
RESULTS: NPSs were found in the above 5 samples, and 3 were confirmed as NPS included in the newly listed controlled substances on July 1, 2024, namely 2-(methylamino)-2-(2-methylphenyl)cyclohexan-1-one (2-MDCK), 2-(ethylamino)-2-(2-fluorophenyl)cyclohexan-l-one (2-FXE), 1-(3,4-methylenedioxyphenyl)-2-(dimethylamino)pentan-1-one (dipentylone), respectively. The first two substances were phencyclidine NPS, and the third substance was synthetic cathinone NPS.
CONCLUSIONS: This study systematically summarizes the distinguishing features of the infrared absorption spectrometry, nuclear magnetic resonance spectroscopy and mass spectrometry of three NPSs, which can provide a reference for the qualitative identification of unknown substances.