Fertility and sterility · 1996
Vascular permeability factor and vascular endothelial growth factor in ovarian hyperstimulation syndrome: a preliminary report.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Krasnow J S, Berga S L, Guzick D S, Zeleznik A J, Yeo K T
Аннотация
OBJECTIVE: To determine whether serum levels of vascular permeability factor (VPF) are elevated in patients with ovarian hyperstimulation syndrome (OHSS) and to determine if luteinizing granulosa cells may be a source of VPF.
DESIGN: Prospective observational study.
SETTING: University IVF and GIFT program.
PATIENTS: Eight consecutive IVF and GIFT patients at high risk for OHSS.
MAIN OUTCOME MEASURES: Vascular permeability factor concentration in serum and follicular fluid.
RESULTS: Serum VPF was significantly higher (15.2 +/- 4.0 pM; mean +/- SEM) on day +14 in the group who developed severe OHSS compared with those who did not. Follicular fluid VPF (171.5 +/- 18.5 pM) was approximately 100-fold greater than serum (1.7 +/- 1.3 pM) or peritoneal fluid (2.5 +/- 1.3 pM) 36 hours after hCG administration.
CONCLUSION: Vascular permeability factor is elevated in patients with severe OHSS and the ovary may be a source of VPF secretion.
DESIGN: Prospective observational study.
SETTING: University IVF and GIFT program.
PATIENTS: Eight consecutive IVF and GIFT patients at high risk for OHSS.
MAIN OUTCOME MEASURES: Vascular permeability factor concentration in serum and follicular fluid.
RESULTS: Serum VPF was significantly higher (15.2 +/- 4.0 pM; mean +/- SEM) on day +14 in the group who developed severe OHSS compared with those who did not. Follicular fluid VPF (171.5 +/- 18.5 pM) was approximately 100-fold greater than serum (1.7 +/- 1.3 pM) or peritoneal fluid (2.5 +/- 1.3 pM) 36 hours after hCG administration.
CONCLUSION: Vascular permeability factor is elevated in patients with severe OHSS and the ovary may be a source of VPF secretion.