Copper-Catalyzed Asymmetric Nucleophilic Substitutions of TsSCF3: Synthesis of Chiral SCF3-Containing Compounds.

By employing electrophilic TsSCF3 as an efficient SCF3 source, we reported Cu/SOP (chiral sulfoxide-phosphine ligand)-catalyzed enantioselective nucleophilic substitutions. Under this protocol, α-pyridyl-α-fluoro esters as latent carbon nucleophiles, compounds containing a C-SCF3 stereocenter along with azacycles and fluorine atoms, were obtained in good yields and enantioselectivities under mild conditions (up to 68% yield, 92% ee).