Oncotarget · 2017
Drug repositioning of mevalonate pathway inhibitors as antitumor agents for ovarian cancer.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
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Kobayashi Yusuke, Kashima Hiroyasu, Rahmanto Yohan Suryo, Banno Kouji, Yu Yu, Matoba Yusuke, Watanabe Keiko, Iijima Moito, Takeda Takashi, Kunitomi Haruko, Iida Miho, Adachi Masataka, Nakamura Kanako, Tsuji Kosuke, Masuda Kenta, Nomura Hiroyuki, Tominaga Eiichiro, Aoki Daisuke
Аннотация
OBJECTIVE: To evaluate the prognostic value of hyoid bone kinematic parameters measured via submental B/M-mode ultrasonography in post-stroke pharyngeal dysphagia, aiming to identify reliable predictors of swallowing recovery.
METHODS: This study included 46 stroke patients with pharyngeal dysphagia, diagnosed via videofluoroscopic swallowing study (VFSS), and treated at the Department of Rehabilitation Medicine, Affiliated Brain Hospital of Nanjing Medical University (June 2020-August 2024). Swallowing function was assessed using seven pharyngeal phase parameters from the Videofluoroscopic Dysphagia Scale (VDS) at baseline and post-rehabilitation. Patients were stratified into favorable (n = 26) and unfavorable (n = 20) prognosis groups based on post-treatment VDS and Functional Oral Intake Scale (FOIS) scores. Submental B/M-mode ultrasonography quantified hyoid bone displacement parameters pre- and post-rehabilitation, including maximum displacement, anterior displacement, superior displacement, total movement duration, and hyoid-thyroid cartilage approximation ratio (ASR).
RESULT: No significant differences were observed between groups in baseline characteristics. Post-treatment, the favorable group showed significantly lower Rosenbek scores (p = 0.000), reduced VDS scores (p = 0.000), and decreased feeding tube dependency (p = 0.000). Post-treatment, the favorable group exhibited greater anterior displacement (p = 0.011), higher ASR (p = 0.000), and shorter total movement duration (p = 0.005). Logistic regression identified hyoid anterior displacement (odds ratio (OR) = 9.539, p = 0.011) and ASR (OR = 14.238, p = 0.001) as independent prognostic predictors. ROC curve analysis indicated that hyoid anterior displacement (area under the curve (AUC) = 0.720) and ASR (AUC = 0.816) were significant discriminators of favorable outcomes, with optimal cutoff values of 0.865 cm (92.3% sensitivity, 50.0% specificity) and 31.5% (84.6% sensitivity, 65.0% specificity), respectively. The combined model further improved predictive accuracy (AUC = 0.854, 84.6% sensitivity, 85.0% specificity).
CONCLUSION: Impaired hyoid anterior displacement and reduced ASR are critical pathophysiological mechanisms in post-stroke dysphagia. Combined assessment of these parameters provides significant clinical utility for prognosis and treatment planning.
METHODS: This study included 46 stroke patients with pharyngeal dysphagia, diagnosed via videofluoroscopic swallowing study (VFSS), and treated at the Department of Rehabilitation Medicine, Affiliated Brain Hospital of Nanjing Medical University (June 2020-August 2024). Swallowing function was assessed using seven pharyngeal phase parameters from the Videofluoroscopic Dysphagia Scale (VDS) at baseline and post-rehabilitation. Patients were stratified into favorable (n = 26) and unfavorable (n = 20) prognosis groups based on post-treatment VDS and Functional Oral Intake Scale (FOIS) scores. Submental B/M-mode ultrasonography quantified hyoid bone displacement parameters pre- and post-rehabilitation, including maximum displacement, anterior displacement, superior displacement, total movement duration, and hyoid-thyroid cartilage approximation ratio (ASR).
RESULT: No significant differences were observed between groups in baseline characteristics. Post-treatment, the favorable group showed significantly lower Rosenbek scores (p = 0.000), reduced VDS scores (p = 0.000), and decreased feeding tube dependency (p = 0.000). Post-treatment, the favorable group exhibited greater anterior displacement (p = 0.011), higher ASR (p = 0.000), and shorter total movement duration (p = 0.005). Logistic regression identified hyoid anterior displacement (odds ratio (OR) = 9.539, p = 0.011) and ASR (OR = 14.238, p = 0.001) as independent prognostic predictors. ROC curve analysis indicated that hyoid anterior displacement (area under the curve (AUC) = 0.720) and ASR (AUC = 0.816) were significant discriminators of favorable outcomes, with optimal cutoff values of 0.865 cm (92.3% sensitivity, 50.0% specificity) and 31.5% (84.6% sensitivity, 65.0% specificity), respectively. The combined model further improved predictive accuracy (AUC = 0.854, 84.6% sensitivity, 85.0% specificity).
CONCLUSION: Impaired hyoid anterior displacement and reduced ASR are critical pathophysiological mechanisms in post-stroke dysphagia. Combined assessment of these parameters provides significant clinical utility for prognosis and treatment planning.