European journal of obstetrics, gynecology, and reproductive biology · 2012
Diagnosing vaginal infections through measurement of biogenic amines by ion mobility spectrometry.
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Sobel Jack D, Karpas Zeev, Lorber Avraham
Аннотация
OBJECTIVE: To compare diagnosis of bacterial vaginosis according to the Amsel criteria with measurement by ion mobility spectrometry (IMS) of the biogenic amines that are present in vaginal discharge fluid.
STUDY DESIGN: Duplicate samples of vaginal fluid were collected from 115 unselected and consecutive patients in a vaginitis clinic in Detroit. All samples were evaluated using Amsel criteria and the results were compared with the diagnosis based on the IMS results.
RESULTS: The incidence rate of vaginal infections was assessed on the basis of both tests and the frequency of BV was found to be 17.4%. The sensitivity and specificity for bacterial vaginosis diagnosis using IMS determination were 95.5% and 98.9%, respectively, with an accuracy of 94.4%.
CONCLUSIONS: The results show that IMS may be used to rapidly diagnose this common vaginal infection with high accuracy.
STUDY DESIGN: Duplicate samples of vaginal fluid were collected from 115 unselected and consecutive patients in a vaginitis clinic in Detroit. All samples were evaluated using Amsel criteria and the results were compared with the diagnosis based on the IMS results.
RESULTS: The incidence rate of vaginal infections was assessed on the basis of both tests and the frequency of BV was found to be 17.4%. The sensitivity and specificity for bacterial vaginosis diagnosis using IMS determination were 95.5% and 98.9%, respectively, with an accuracy of 94.4%.
CONCLUSIONS: The results show that IMS may be used to rapidly diagnose this common vaginal infection with high accuracy.