Toxicology and hazard evaluation of cyanide fumigation powders.

Studies were conducted to assess potential handling hazards from the pesticidal use of HCN-liberating "cyanide fumigation powders". Simulations were conducted in enclosed chambers on the release of HCN vapor from wetted powder containing 40% NaCN/60% kaolin at application rates of 1 g powder/m3 of space (usual rate) and 5 g/m3 (overuse condition). With the overuse situation, HCN vapor concentrations may be rapidly attained that produce serious or lethal toxicity; with the lower application rate minor signs and symptoms of HCN vapor exposure toxicity may develop. The acute peroral LD50 (rat and rabbit) of fumigant formulation is reduced in proportion to the kaolin content, but kaolin does not modify the inherent toxicity of NaCN. A typical cyanide hazard exists from swallowing cyanide fumigant powder formulations. Lethal systemic toxicity was produced by contamination of the eye (rabbit) with powder formulation, which also caused a rapid onset of moderately severe conjunctivitis and keratitis. Applied to dry intact skin (rabbit) neither NaCN nor its kaolin formulation produced systemic toxicity. However, on moistened intact skin lethal amounts of cyanide were absorbed; but the kaolin content reduced the hazard in comparison with NaCN-alone applied to moist skin. With abraded dry skin there was no difference in lethal toxicity between NaCN-alone and its formulation; also, the toxicity of the formulation on abraded skin was three times that on intact moist skin. These finds indicate that the use of cyanide fumigant powder formulations may be hazardous by contact of powder with moist or abraded skin, contamination of the eye, swallowing, and inhalation of evolved HCN. There is a clear need for respiratory, cutaneous, and ocular protection when handling cyanide fumigant powder formulations.