Antimicrobial and antimalarial activity of Cussonia species (Araliaceae).

ETHNOPHARMACOLOGICAL RELEVANCE: Cussonia species are used in African traditional medicine mainly against pain, inflammation, gastro-intestinal problems, malaria and sexually transmitted diseases.

AIM OF THE STUDY: To summarise ethnomedicinal uses of Cussonia and to find scientific evidence in support of selected main uses.

MATERIALS AND

METHODS

Using the minimum inhibitory concentration (MIC) method, leaves of 13 Cussonia species, Schefflera umbellifera and Seemannaralia gerrardii were tested against pathogens associated with diarrhoea (Enterococcus faecalis and Escherichia coli), sexually transmitted infections (Neisseria gonorrhoeae and Trichomonas vaginalis) and general infectious diseases (Staphylococcus aureus and Pseudomonas aeruginosa). Antimalarial sensitivity was studied using Plasmodium falciparum and the [(3)H]-hypoxanthine incorporation assay. Cytotoxic effects on a T-cell leukaemia (Jurkat) cell line were determined using the tetrazolium-based cellular toxicity assay.

RESULTS

Methanolic extracts were active against Pseudomonas aeruginosa (MIC of 1.0-1.5 mg/mL), Trichomonas vaginalis (MIC of 0.8-1.3 mg/mL) and Staphylococcus aureus (Cussonia arborea, 1.8 mg/mL). All samples were active against Neisseria gonorrhoeae (MIC of 0.02-0.7 mg/mL). The methanol extract of Cussonia arborea was the most active against Plasmodium falciparum (13.68 microg/mL) and showed anticancer properties (5.60 microg/mL).

CONCLUSIONS

The traditional use of Cussonia species to treat sexually transmitted diseases and Plasmodium infections appears to have a scientific basis.