Diabetes research and clinical practice · 2025
Kidney function decline mediates the adverse effects of arterial stiffness on all-cause and cardiovascular disease mortality in Cardiovascular-Kidney-Metabolic syndrome population: A cohort study.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Liu Song, Man Qizhang, Wang Shuan, Huang Yifeng, Wen Jinfeng, Yang Ying, Xie Hao, Fan Lei
Аннотация
UNLABELLED: AIDS: Cardiovascular-Kidney-Metabolic (CKM) syndrome links metabolic, renal, and cardiovascular disorders. The prognostic value and mechanisms of estimated pulse wave velocity (ePWV) in CKM syndrome remain unclear.
METHODS: We analyzed 34,004 CKM syndrome patients from NHANES 1999-2018. Cox regression, restricted cubic splines, and mediation analyses examined ePWV-mortality associations and renal function's mediating role.
RESULTS: Over 104 months median follow-up, 4,141 all-cause and 1,261 cardiovascular deaths occurred. In fully adjusted model, each unit ePWV increase associated with 32 % higher all-cause mortality (HR: 1.32, 95 % CI: 1.29-1.35) and 34 % higher CVD mortality (HR: 1.34, 95 % CI: 1.28-1.40). The association showed L-shaped patterns in non-advanced CKM cases and linear relationships in advanced stages. Kidney function decline mediated 24 % of all-cause and 26 % of CVD mortality risk.
CONCLUSIONS: Elevated ePWV predicts increased mortality in CKM syndrome patients, with kidney function decline as a significant mediating pathway. These findings highlight the importance of arterial stiffness assessment and renal protection in CKM management.
METHODS: We analyzed 34,004 CKM syndrome patients from NHANES 1999-2018. Cox regression, restricted cubic splines, and mediation analyses examined ePWV-mortality associations and renal function's mediating role.
RESULTS: Over 104 months median follow-up, 4,141 all-cause and 1,261 cardiovascular deaths occurred. In fully adjusted model, each unit ePWV increase associated with 32 % higher all-cause mortality (HR: 1.32, 95 % CI: 1.29-1.35) and 34 % higher CVD mortality (HR: 1.34, 95 % CI: 1.28-1.40). The association showed L-shaped patterns in non-advanced CKM cases and linear relationships in advanced stages. Kidney function decline mediated 24 % of all-cause and 26 % of CVD mortality risk.
CONCLUSIONS: Elevated ePWV predicts increased mortality in CKM syndrome patients, with kidney function decline as a significant mediating pathway. These findings highlight the importance of arterial stiffness assessment and renal protection in CKM management.