American journal of perinatology · 2008
The effect of body mass index on therapeutic response to bacterial vaginosis in pregnancy.
СтатьяПоддержка NIH: внешняя программаНазвание и аннотация: Перевод в очереди
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Mastrobattista Joan M, Klebanoff Mark A, Carey J Christopher, Hauth John C, Macpherson Cora A, Ernest J, Cotroneo Margaret, Leveno Kenneth J, Wapner Ronald, Varner Michael, Iams Jay D, Moawad Atef, Sibai Baha M, Miodovnik Menachem, Dombrowski Mitchell, O'Sullivan Mary J, Vandorsten J Peter, Langer Oded, National Institute of Child Health and Human Development Maternal-Fetal Medicine Unit Networks
Аннотация
Our objective was to determine the effect of body mass index (BMI) on response to bacterial vaginosis (BV) treatment. A secondary analysis was conducted of two multicenter trials of therapy for BV and TRICHOMONAS VAGINALIS. Gravida were screened for BV between 8 and 22 weeks and randomized between 16 and 23 weeks to metronidazole or placebo. Of 1497 gravida with asymptomatic BV and preconceptional BMI, 738 were randomized to metronidazole; BMI was divided into categories: < 25, 25 to 29.9, and > or = 30. Rates of BV persistence at follow-up were compared using the Mantel-Haenszel chi square. Multiple logistic regression was used to evaluate the effect of BMI on BV persistence at follow-up, adjusting for potential confounders. No association was identified between BMI and BV rate at follow-up ( P = 0.21). BMI was associated with maternal age, smoking, marital status, and black race. Compared with women with BMI of < 25, adjusted odds ratio (OR) of BV at follow-up were BMI 25 to 29.9: OR, 0.66, 95% CI 0.43 to 1.02; BMI > or = 30: OR, 0.83, 95% CI 0.54 to 1.26. We concluded that the persistence of BV after treatment was not related to BMI.