Медицинская библиотека · Science (New York, N.Y.) · 2007

Draft genome sequence of the sexually transmitted pathogen Trichomonas vaginalis.

Carlton Jane M, Hirt Robert P, Silva Joana C, Delcher Arthur L, Schatz Michael, Zhao Qi, Wortman Jennifer R, Bidwell Shelby L, Alsmark U Cecilia M, Besteiro Sébastien, Sicheritz-Ponten Thomas, Noel Christophe J, Dacks Joel B, Foster Peter G, Simillion Cedric, Van de Peer Yves, Miranda-Saavedra Diego, Barton Geoffrey J, Westrop Gareth D, Müller Sylke, Dessi Daniele, Fiori Pier Luigi, Ren Qinghu, Paulsen Ian, Zhang Hanbang, Bastida-Corcuera Felix D, Simoes-Barbosa Augusto, Brown Mark T, Hayes Richard D, Mukherjee Mandira, Okumura Cheryl Y, Schneider Rachel, Smith Alias J, Vanacova Stepanka, Villalvazo Maria, Haas Brian J, Pertea Mihaela, Feldblyum Tamara V, Utterback Terry R, Shu Chung-Li, Osoegawa Kazutoyo, de Jong Pieter J, Hrdy Ivan, Horvathova Lenka, Zubacova Zuzana, Dolezal Pavel, Malik Shehre-Banoo, Logsdon John M, Henze Katrin, Gupta Arti, Wang Ching C, Dunne Rebecca L, Upcroft Jacqueline A, Upcroft Peter, White Owen, Salzberg Steven L, Tang Petrus, Chiu Cheng-Hsun, Lee Ying-Shiung, Embley T Martin, Coombs Graham H, Mottram Jeremy C, Tachezy Jan, Fraser-Liggett Claire M, Johnson Patricia J

СтатьяПоддержка NIH: внешняя программаПоддержка исследования: вне правительства СШАПеревод в очереди

Аннотация

We describe the genome sequence of the protist Trichomonas vaginalis, a sexually transmitted human pathogen. Repeats and transposable elements comprise about two-thirds of the approximately 160-megabase genome, reflecting a recent massive expansion of genetic material. This expansion, in conjunction with the shaping of metabolic pathways that likely transpired through lateral gene transfer from bacteria, and amplification of specific gene families implicated in pathogenesis and phagocytosis of host proteins may exemplify adaptations of the parasite during its transition to a urogenital environment. The genome sequence predicts previously unknown functions for the hydrogenosome, which support a common evolutionary origin of this unusual organelle with mitochondria.

Для цитирования: Carlton Jane M, Hirt Robert P, Silva Joana C, Delcher Arthur L, Schatz Michael, Zhao Qi, Wortman Jennifer R, Bidwell Shelby L, Alsmark U Cecilia M, Besteiro Sébastien, Sicheritz-Ponten Thomas, Noel Christophe J, Dacks Joel B, Foster Peter G, Simillion Cedric, Van de Peer Yves, Miranda-Saavedra Diego, Barton Geoffrey J, Westrop Gareth D, Müller Sylke, Dessi Daniele, Fiori Pier Luigi, Ren Qinghu, Paulsen Ian, Zhang Hanbang, Bastida-Corcuera Felix D, Simoes-Barbosa Augusto, Brown Mark T, Hayes Richard D, Mukherjee Mandira, Okumura Cheryl Y, Schneider Rachel, Smith Alias J, Vanacova Stepanka, Villalvazo Maria, Haas Brian J, Pertea Mihaela, Feldblyum Tamara V, Utterback Terry R, Shu Chung-Li, Osoegawa Kazutoyo, de Jong Pieter J, Hrdy Ivan, Horvathova Lenka, Zubacova Zuzana, Dolezal Pavel, Malik Shehre-Banoo, Logsdon John M, Henze Katrin, Gupta Arti, Wang Ching C, Dunne Rebecca L, Upcroft Jacqueline A, Upcroft Peter, White Owen, Salzberg Steven L, Tang Petrus, Chiu Cheng-Hsun, Lee Ying-Shiung, Embley T Martin, Coombs Graham H, Mottram Jeremy C, Tachezy Jan, Fraser-Liggett Claire M, Johnson Patricia J. Draft genome sequence of the sexually transmitted pathogen Trichomonas vaginalis.. Science (New York, N.Y.). 2007. DOI: 10.1126/science.1132894.

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