Prevalence and Relative Proportions of Multiple Sclerosis, Neuromyelitis Optica Spectrum Disorder, and Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease in the Republic of Korea.
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Kim Su-Hyun, Lee Eun-Jae, Lim Young-Min, Kim Hyunjin, Min Ju-Hong, Choo Seung Ho, Kim Byoung Joon, Kim Sung-Min, Ohn Dong Seok, Shin Ha Young, Kim Ki Hoon, Kwon Young Nam, Kim Seung Woo, Kim Jun-Soon, Kim Woojun, Sohn Eunhee, Kim Sooyoung, Seok Jin Myoung, Nam Tai-Seung, Kang You-Ri, Park Minsu, Shin Kyong Jin, Kim Byung-Jo, Baek Seol-Hee, Park Jin-Woo, Oh Sun-Young, Park Young Eun, Hong Yoon-Ho, Ahn Suk-Won, Ju Woohee, Oh Jeeyoung, Lee Hye Lim, Lee Tae-Kyeong, Jeon Byeong-Jun, Kim Nam-Hee, Kim Sunyoung, Kwon Soonwook, Yoon Byeol-A, Kim Jong Kuk, Park Jinseok, Bong Jeong Bin, Cho Eun Bin, Kim Yoo Hwan, Bae Jong Seok, Oh Seong-Il, Sung Sang Yoon, Yang Jiwon, Kim Do-Hyung, Kim Jee-Eun, Kim Juhyeon, Shin Hyun-June, Kwon Ohyun, Kim Ahwon, Kang Sa-Yoon, Seok Jung Im, Kang Minsung, Sung Joo Hye, Seok Hung Youl, Shin Jin-Hong, Choi Jae-Hwan, Kim Dae-Seong, Min Je Hong, Joo In Soo, So Jungmin, Hyun Jae-Won, Kim Ho Jin
Аннотация
METHODS: From January to March 2025, 47 referral hospitals participating in a nationwide hospital-based registry identified actively followed patients with MS, NMOSD, or MOGAD. Diagnoses followed international criteria, and antibody status was confirmed using validated CBAs. Actively followed patients had ≥1 outpatient visit in the prior 6 months. Centers provided demographics, treatments, and Expanded Disability Status Scale. Prevalence used national population data.
RESULTS: A total of 4,196 patients were identified, 1,799 MS, 1,616 NMOSD, and 781 MOGAD (ratio 2.3:2.1:1). Mean age at onset was 33.4 ± 12.0 years for MS, 42.7 ± 14.7 for NMOSD, and 41.7 ± 17.8 for MOGAD, and the female-to-male ratios were 2.2:1 for MS, 5.1:1 for NMOSD (6.5:1 in aquaporin-4-IgG positive cases), and 1.5:1 for MOGAD. Crude prevalence estimates were 3.48, 3.13, and 1.51 per 100,000, respectively.
DISCUSSION: This nationwide registry demonstrates a distinctive Korean CNS inflammatory demyelinating disease profile, with a relatively higher proportion of NMOSD and MOGAD reflecting the low prevalence of MS in East Asia.