Decarboxylative sulfinamidation of N-sulfinylamines with carboxylic acids via a photochemical iron-mediated ligand-to-metal charge transfer process.

Sulfinamides are valuable four-valent sulfur compounds in medicinal chemistry, yet methods relying on simple and readily available feedstocks are scarce. Herein, a novel and efficient strategy was developed to facilitate the direct decarboxylative sulfinamidation of carboxylic acids via a photoinduced iron-mediated ligand-to-metal charge-transfer process. Notably, this protocol exemplifies an environmentally benign approach to the synthesis of a range of structurally diverse sulfinamides with an excellent functional group compatibility, thereby rendering it suitable for the late-stage modification of bioactive molecules.