Sexually transmitted diseases · 2003
Influence of HIV-1 coinfection on effective management of abnormal vaginal discharge.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Moodley Prashini, Wilkinson David, Connolly Cathy, Sturm A Willem
Аннотация
BACKGROUND: Reports on microbiologic cure rates following syndromic management (SM) of women with nonulcerative sexually transmitted infections (STIs) are limited.
GOAL: The goal of the study was to determine the effectiveness of the drugs used in SM of nonulcerative STIs and bacterial vaginosis in women and to compare the response among those with and without HIV-1 coinfection.
STUDY DESIGN: This was a cohort study of women with nonulcerative STIs who were treated according to local SM protocols.
RESULTS: Of 692 women recruited, 415 (80%) returned 8 to 10 days later, and 290 (70%) consented to a second examination, in which specimens were obtained. Clinical cure was reported by 67%, and microbiologic cure ranged from 80% to 89% for the three discharge-causing STIs and was independent of HIV-1 status. Only 38% of those with bacterial vaginosis were cured, and HIV-1-infected women were less likely to be cured (28% versus 52%; P < 0.001).
CONCLUSIONS: Clinical and microbiologic response to SM of the nonulcerative STIs was not affected by HIV-1 coinfection, but cure rates for bacterial vaginosis were reduced.
GOAL: The goal of the study was to determine the effectiveness of the drugs used in SM of nonulcerative STIs and bacterial vaginosis in women and to compare the response among those with and without HIV-1 coinfection.
STUDY DESIGN: This was a cohort study of women with nonulcerative STIs who were treated according to local SM protocols.
RESULTS: Of 692 women recruited, 415 (80%) returned 8 to 10 days later, and 290 (70%) consented to a second examination, in which specimens were obtained. Clinical cure was reported by 67%, and microbiologic cure ranged from 80% to 89% for the three discharge-causing STIs and was independent of HIV-1 status. Only 38% of those with bacterial vaginosis were cured, and HIV-1-infected women were less likely to be cured (28% versus 52%; P < 0.001).
CONCLUSIONS: Clinical and microbiologic response to SM of the nonulcerative STIs was not affected by HIV-1 coinfection, but cure rates for bacterial vaginosis were reduced.
Предметные рубрики MeSH
AdolescentAdultAnimalsAnti-Bacterial AgentsAnti-Infective AgentsChlamydia trachomatisCiprofloxacinCohort StudiesDoxycyclineDrug Administration ScheduleDrug Therapy, CombinationFemaleHIV InfectionsHIV-1HumansMetronidazoleMiddle AgedNeisseria gonorrhoeaePrevalenceSouth AfricaTreatment OutcomeTrichomonas vaginalisVaginitis