Journal of perinatology : official journal of the California Perinatal Association · 2019
Early predictors of continuous positive airway pressure failure in preterm neonates.
СтатьяВалидационное исследованиеНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
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Kakkilaya Venkatakrishna, Wagner Sheron, Mangona Kate Louise M, Steven Brown L, Jubran Ihab, He Henry, Savani Rashmin C, Kapadia Vishal S
Аннотация
OBJECTIVE: To develop a prediction model to identify infants admitted on continuous positive airway pressure (CPAP) requiring intubation within seventy-two hours of life (HOL).
STUDY DESIGN: Infants born ≤29 weeks' gestational age between 2013 and April 2018 were randomly assigned to either a modeling cohort (MC) or a validation cohort (VC) in a 2:1 ratio. Variables available within two HOL were compared between the CPAP failure group (CFG) and the CPAP success group (CSG).
RESULTS: Of the 189 infants in the MC, 50% failed CPAP. Compared to CSG, infants in the CFG had lower antenatal steroid exposure, birth weight, higher radiographic severe respiratory distress syndrome (RDS) and fraction of inspired oxygen (FiO2). A forward stepwise logistic regression modeling in both MC and VC showed that FiO2 >0.3 and radiographic severe RDS predicted CPAP failure.
CONCLUSION: FiO2 >0.3 within two HOL and radiographic severe RDS predicts CPAP failure in preterm infants.
STUDY DESIGN: Infants born ≤29 weeks' gestational age between 2013 and April 2018 were randomly assigned to either a modeling cohort (MC) or a validation cohort (VC) in a 2:1 ratio. Variables available within two HOL were compared between the CPAP failure group (CFG) and the CPAP success group (CSG).
RESULTS: Of the 189 infants in the MC, 50% failed CPAP. Compared to CSG, infants in the CFG had lower antenatal steroid exposure, birth weight, higher radiographic severe respiratory distress syndrome (RDS) and fraction of inspired oxygen (FiO2). A forward stepwise logistic regression modeling in both MC and VC showed that FiO2 >0.3 and radiographic severe RDS predicted CPAP failure.
CONCLUSION: FiO2 >0.3 within two HOL and radiographic severe RDS predicts CPAP failure in preterm infants.
Предметные рубрики MeSH
Continuous Positive Airway PressureHumansInfant, Extremely PrematureInfant, NewbornInfant, PrematureIntubation, IntratrachealLogistic ModelsModels, BiologicalOxygenPatient AcuityRadiography, ThoracicRandom AllocationRespiratory Distress Syndrome, NewbornRetrospective StudiesRisk FactorsTreatment Failure