Mediators of inflammation · 2026
Synergistic Alleviation of Inflammatory Cytokine Storms in Sepsis Rats by Low-Intensity Pulsed Ultrasound and Imipenem.
СтатьяНазвание и аннотация: Перевод в очереди
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Tang Wentao, Deng Juan, Zhang Xinyi, Song Guolin, Qin Juan, Li Chenghai, Xiao Xinfang, Wu Liu, Tang Yilin, Zhou Yiqing, Li Junfen, He Sicheng, Wang Yan
Аннотация
AIMS: This study aimed to investigate the effects of low intensity pulsed ultrasound (LIPUS) combined with imipenem (IMI) on inflammatory responses and organ protection in septic rats.
RESULTS: The study involved 230 Sprague-Dawley (SD) rats, with 80 used for survival analysis and 150 for sampling over 72 h. Histological examination (hematoxylin and eosin [H&E] staining) and transmission electron microscopy (TEM) revealed that LIPUS combined with IMI significantly alleviated spleen tissue damage and reduced mitochondrial edema. Key inflammatory cytokines, such as interleukin-1 beta (IL-1β), tumor necrosis factor-alpha (TNF-α), and IL-6 were significantly decreased, while IL-10 levels increased in the LIPUS + IMI group (p < 0.05). The combined treatment also reduced the expression of cytokines, such as IL-1 receptor (IL-1R), nuclear factor kappa B p65 (NF-κB p65), transforming growth factor-beta (TGF-β), and high mobility group protein box 1 (HMGB1), indicating a reduction in inflammation (p < 0.05).
CONCLUSION AND INNOVATION: This study presents a novel approach by integrating LIPUS with IMI, providing a noninvasive and effective strategy to mitigate cytokine storms, optimize antibiotic use, and reduce organ damage in sepsis. The protective effects observed are primarily attributed to the inhibition of the IL-1R/NF-κB signaling pathway, which significantly improves survival outcomes in septic rats. This combined therapy has potential for enhancing sepsis treatment protocols.
RESULTS: The study involved 230 Sprague-Dawley (SD) rats, with 80 used for survival analysis and 150 for sampling over 72 h. Histological examination (hematoxylin and eosin [H&E] staining) and transmission electron microscopy (TEM) revealed that LIPUS combined with IMI significantly alleviated spleen tissue damage and reduced mitochondrial edema. Key inflammatory cytokines, such as interleukin-1 beta (IL-1β), tumor necrosis factor-alpha (TNF-α), and IL-6 were significantly decreased, while IL-10 levels increased in the LIPUS + IMI group (p < 0.05). The combined treatment also reduced the expression of cytokines, such as IL-1 receptor (IL-1R), nuclear factor kappa B p65 (NF-κB p65), transforming growth factor-beta (TGF-β), and high mobility group protein box 1 (HMGB1), indicating a reduction in inflammation (p < 0.05).
CONCLUSION AND INNOVATION: This study presents a novel approach by integrating LIPUS with IMI, providing a noninvasive and effective strategy to mitigate cytokine storms, optimize antibiotic use, and reduce organ damage in sepsis. The protective effects observed are primarily attributed to the inhibition of the IL-1R/NF-κB signaling pathway, which significantly improves survival outcomes in septic rats. This combined therapy has potential for enhancing sepsis treatment protocols.