Trends of Adverse Pregnancy Outcomes in a High Prevalence Region of Birth Defects - Shanxi Province, China, 2007-2019.

What is already known about this topic? Shanxi Province in northern China has been identified as a region with the highest prevalence of birth defects nationwide. With large amounts of financial support devoted for prevention and related interventions for birth defects, huge progress has been made as a 60% decrease in its prevalence was observed from 2009 to 2014. What is added by this report? The study presented a recent trend of adverse pregnancy outcomes (APOs) in Shanxi Province, a region with high prevalence of birth defects in China from 2007-2019. The prevalence of serious APOs including birth defects, stillbirths, and neonatal deaths remained at a relatively low level, yet macrosomia, low birth weight (LBW), preterm births, and spontaneous abortion comprised a majority of all APOs, with macrosomia showing an obvious upward trend from 2007 to 2012. What are the implications for public health practice? These findings provide new evidence for prevention and intervention strategies of APOs in northern China. Future research should focus on comprehensive interventions for multiple APOs, especially macrosomia, LBW, preterm births, and spontaneous abortion.