[The relationship between the pathological classifications and molecular genetics of hydatidiform moles].

OBJECTIVE

To study the relationship between the pathological classification and molecular genetics of hydatidiform mole.

METHOD: 32 cases of hydatidiform mole were analyzed by DNA restriction fragment length polymorphism (RFLP, hybridized with the probe 33.15).

RESULTS

DNA from only paternal origin was found in 21, and from both parents in 11. In the formeron the basis of pathological characteristics, the complete hydatidiform mole (CHM) and the partial hydatidiform mole (PHM) were 16 (76%, 16/21) and 5 (24%, 5/21) respectively, and in the later CHM and PHM were 5 (45%, 5/11) and 6 (55%, 6/11), respectively.

CONCLUSION

There is not much correlation between pathological classification and molecular genetics of hydatidiform mole.