Nature medicine · 2021
Attributes and predictors of long COVID.
СтатьяПоддержка NIH: внешняя программаПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Sudre Carole H, Murray Benjamin, Varsavsky Thomas, Graham Mark S, Penfold Rose S, Bowyer Ruth C, Pujol Joan Capdevila, Klaser Kerstin, Antonelli Michela, Canas Liane S, Molteni Erika, Modat Marc, Jorge Cardoso M, May Anna, Ganesh Sajaysurya, Davies Richard, Nguyen Long H, Drew David A, Astley Christina M, Joshi Amit D, Merino Jordi, Tsereteli Neli, Fall Tove, Gomez Maria F, Duncan Emma L, Menni Cristina, Williams Frances M K, Franks Paul W, Chan Andrew T, Wolf Jonathan, Ourselin Sebastien, Spector Tim, Steves Claire J
Аннотация
Reports of long-lasting coronavirus disease 2019 (COVID-19) symptoms, the so-called 'long COVID', are rising but little is known about prevalence, risk factors or whether it is possible to predict a protracted course early in the disease. We analyzed data from 4,182 incident cases of COVID-19 in which individuals self-reported their symptoms prospectively in the COVID Symptom Study app1. A total of 558 (13.3%) participants reported symptoms lasting ≥28 days, 189 (4.5%) for ≥8 weeks and 95 (2.3%) for ≥12 weeks. Long COVID was characterized by symptoms of fatigue, headache, dyspnea and anosmia and was more likely with increasing age and body mass index and female sex. Experiencing more than five symptoms during the first week of illness was associated with long COVID (odds ratio = 3.53 (2.76-4.50)). A simple model to distinguish between short COVID and long COVID at 7 days (total sample size, n = 2,149) showed an area under the curve of the receiver operating characteristic curve of 76%, with replication in an independent sample of 2,472 individuals who were positive for severe acute respiratory syndrome coronavirus 2. This model could be used to identify individuals at risk of long COVID for trials of prevention or treatment and to plan education and rehabilitation services.