Expert review of anti-infective therapy · 2026
Effectiveness of bundles to prevent surgical site infections in cranial neurosurgery: systematic review, meta-analysis, and GRADE evaluation.
СтатьяМетаанализСистематический обзорНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
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Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Paranhos Andressa Caroline, Resende Mariângela Ribeiro, Psaltikidis Eliane Molina, de Noce Leonardo Pires, Evangelista-Poderoso Rosana
Аннотация
INTRODUCTION: Cranial neurosurgery involves high-risk procedures with major clinical and economic implications. Effective preventive measures against surgical site infections (SSIs) can reduce morbidity, mortality, and healthcare costs. This systematic review and meta-analysis evaluated the effectiveness of care bundles in preventing SSIs in cranial neurosurgery.
METHODS: Following PRISMA guidelines, a systematic search identified controlled studies (2014-2024) evaluating SSI prevention bundles in cranial neurosurgery. Meta-regression was performed, and evidence certainty was assessed using GRADE.
RESULTS: Of 3945 records, 14 studies met inclusion criteria. Bundles integrated pre-, intra-, and postoperative measures. Implementation significantly reduced SSI incidence (pooled odds ratio [OR] 0.34; 95% confidence interval [CI] 0.23-0.51; p < 0.01). The presence of antimicrobial prophylaxis within bundles was associated with lower SSI risk (OR 0.45; 95% CI 0.22-0.92; p = 0.031). Evidence certainty was rated low, mainly due to observational design, though risk of bias, imprecision, and inconsistency were minimal.
CONCLUSION: Standardized care bundles effectively prevent SSIs in cranial neurosurgery, particularly when antimicrobial prophylaxis is included. These findings support adopting multimodal, evidence-based strategies in perioperative infection prevention protocols.
REGISTRATION: The study protocol was registered with the Open Science Framework (OSF) Registries prior to the literature search and is available from: https://doi.org/10.17605/OSF.IO/UBZW7.
METHODS: Following PRISMA guidelines, a systematic search identified controlled studies (2014-2024) evaluating SSI prevention bundles in cranial neurosurgery. Meta-regression was performed, and evidence certainty was assessed using GRADE.
RESULTS: Of 3945 records, 14 studies met inclusion criteria. Bundles integrated pre-, intra-, and postoperative measures. Implementation significantly reduced SSI incidence (pooled odds ratio [OR] 0.34; 95% confidence interval [CI] 0.23-0.51; p < 0.01). The presence of antimicrobial prophylaxis within bundles was associated with lower SSI risk (OR 0.45; 95% CI 0.22-0.92; p = 0.031). Evidence certainty was rated low, mainly due to observational design, though risk of bias, imprecision, and inconsistency were minimal.
CONCLUSION: Standardized care bundles effectively prevent SSIs in cranial neurosurgery, particularly when antimicrobial prophylaxis is included. These findings support adopting multimodal, evidence-based strategies in perioperative infection prevention protocols.
REGISTRATION: The study protocol was registered with the Open Science Framework (OSF) Registries prior to the literature search and is available from: https://doi.org/10.17605/OSF.IO/UBZW7.