Microorganisms · 2021
COVID-19 Infection in Children, Infants and Pregnant Subjects: An Overview of Recent Insights and Therapies.
СтатьяОбзорНазвание и аннотация: Перевод в очереди
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Malcangi Giuseppina, Inchingolo Alessio Danilo, Inchingolo Angelo Michele, Santacroce Luigi, Marinelli Grazia, Mancini Antonio, Vimercati Luigi, Maggiore Maria Elena, D'Oria Maria Teresa, Hazballa Denisa, Bordea Ioana Roxana, Xhajanka Edit, Scarano Antonio, Farronato Marco, Tartaglia Gianluca Martino, Giovanniello Delia, Nucci Ludovica, Serpico Rosario, Sammartino Gilberto, Capozzi Loredana, Parisi Antonio, Di Domenico Marina, Lorusso Felice, Contaldo Maria, Inchingolo Francesco, Dipalma Gianna
Аннотация
BACKGROUND: The SARS-CoV-2 pandemic has involved a severe increase of cases worldwide in a wide range of populations. The aim of the present investigation was to evaluate recent insights about COVID-19 infection in children, infants and pregnant subjects.
METHODS: a literature overview was performed including clinical trials, in vitro studies, reviews and published guidelines regarding the present paper topic. A descriptive synthesis was performed to evaluate recent insights and the effectiveness of therapies for SARS-CoV-2 infection in children, infants and pregnant subjects.
RESULTS: Insufficient data are available regarding the relationship between COVID-19 and the clinical risk of spontaneous abortion and premature foetus death. A decrease in the incidence of COVID-19 could be correlated to a minor expression of ACE2 in childrens' lungs. At present, a modulation of the dose-effect posology for children and infants is necessary.
CONCLUSIONS: Pregnant vertical transmission has been hypothesised for SARS-CoV-2 infection. Vaccines are necessary to achieve mass immunity for children and also pregnant subjects.
METHODS: a literature overview was performed including clinical trials, in vitro studies, reviews and published guidelines regarding the present paper topic. A descriptive synthesis was performed to evaluate recent insights and the effectiveness of therapies for SARS-CoV-2 infection in children, infants and pregnant subjects.
RESULTS: Insufficient data are available regarding the relationship between COVID-19 and the clinical risk of spontaneous abortion and premature foetus death. A decrease in the incidence of COVID-19 could be correlated to a minor expression of ACE2 in childrens' lungs. At present, a modulation of the dose-effect posology for children and infants is necessary.
CONCLUSIONS: Pregnant vertical transmission has been hypothesised for SARS-CoV-2 infection. Vaccines are necessary to achieve mass immunity for children and also pregnant subjects.