Clinica chimica acta; international journal of clinical chemistry · 2026
Low plasma vitamin B6 levels are independently associated with ischemic stroke risk in young south Indian adults: A case-control study.
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Rudreshkumar Kondapura Jayadevappa, Pandarisamy Sundaravadivel, Nagaraja Dindagur, Christopher Rita
Аннотация
BACKGROUND: Ischemic stroke among young adults is a significant public health concern globally. Given vitamin B6's critical roles in homocysteine metabolism and oxidative stress regulation, we aimed to investigate the association between plasma vitamin B6 levels and the risk of ischemic stroke in young South Indian adults.
METHODS: This case-control study included 171 young ischemic stroke patients and 249 age-matched healthy controls. Plasma vitamin B6 and total homocysteine (tHcy) levels were quantified using ion-pairing reverse-phase high-performance liquid chromatography (RP-HPLC), while plasma vitamin B12 and folate were measured via chemiluminescence immunoassay. Serum malondialdehyde (MDA) and ferric reducing antioxidant power (FRAP) were determined by spectrofluorimetry and spectrophotometry, respectively.
RESULTS: Median plasma vitamin B6 levels were significantly lower in ischemic stroke patients (40.9 nmol/L) than in controls (65.6 nmol/L; p < 0.0001). Vitamin B6 insufficiency (<30 nmol/L) was present in 12.3% of cases and 0.7% in controls. Lower vitamin B6 levels were independently associated with increased stroke risk (adjusted odds ratio = 1.53; p < 0.0001). In stroke cases, vitamin B6 levels correlated negatively with tHcy (r = -0.886) and MDA (r = -0.295). ROC analysis demonstrated excellent discriminative power for vitamin B6 (AUC = 0.929), indicating strong potential as a biomarker for ischemic stroke risk in young individuals.
CONCLUSION: In conclusion, it was clearly observed that reduced levels of vitamin B6 had a significant association with ischemic stroke in young adults. To further extend this knowledge on the effects of vitamin B6 in young adults, additional studies need to be conducted.
METHODS: This case-control study included 171 young ischemic stroke patients and 249 age-matched healthy controls. Plasma vitamin B6 and total homocysteine (tHcy) levels were quantified using ion-pairing reverse-phase high-performance liquid chromatography (RP-HPLC), while plasma vitamin B12 and folate were measured via chemiluminescence immunoassay. Serum malondialdehyde (MDA) and ferric reducing antioxidant power (FRAP) were determined by spectrofluorimetry and spectrophotometry, respectively.
RESULTS: Median plasma vitamin B6 levels were significantly lower in ischemic stroke patients (40.9 nmol/L) than in controls (65.6 nmol/L; p < 0.0001). Vitamin B6 insufficiency (<30 nmol/L) was present in 12.3% of cases and 0.7% in controls. Lower vitamin B6 levels were independently associated with increased stroke risk (adjusted odds ratio = 1.53; p < 0.0001). In stroke cases, vitamin B6 levels correlated negatively with tHcy (r = -0.886) and MDA (r = -0.295). ROC analysis demonstrated excellent discriminative power for vitamin B6 (AUC = 0.929), indicating strong potential as a biomarker for ischemic stroke risk in young individuals.
CONCLUSION: In conclusion, it was clearly observed that reduced levels of vitamin B6 had a significant association with ischemic stroke in young adults. To further extend this knowledge on the effects of vitamin B6 in young adults, additional studies need to be conducted.