Molekuliarnaia genetika, mikrobiologiia i virusologiia · 2013
[Association of the polymorphism of dna repair genes with chromosomal aberrations in lung cancer patients].
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Bakanova M L, Minina V I, Savchenko Ia A, Timofeeva A A, Dudkina O A, Titov V A, Verzhbitskaia N E
Аннотация
The results of the examination of association of polymorphisms of DNA repair genes and chromosomal aberrations in lung cancer patients are discussed. A significant positive association between the hOGG1 G/G genotypes, XPD G/G genotype and lung cancer was found. The hOGG1 C/C genotypes were significantly negatively associated with lung cancer. The patient chromosomal aberration frequencies were significantly higher than in control. Carriers of all APE1 and XPD genotypes, XRCC1 G/G genotype, ADPRT T/T genotype, hOGG1 C/C and Ser/Cys genotypes had statistically significant differences in the level of the chromosomal aberrations between patient and control groups. Statistically significant differences in the level of chromosomal aberrations between XPD T/T and G/G genotype of lung cancer patients were observed.