Journal of complementary & integrative medicine · 2026
Hydroethanolic root extract of Ficus capensis exhibits antiulcerogenic activities in acetic acid-induced colitis rat model.
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Owusu George, Antwi-Adjei Meshack, Opoku-Yeboah Yeboaba Kofi, Tuatil Barnabas, Adu-Boateng Abigail, Baidoo Frederick Emmanuel, Abrokwah Francis Kwame, Aboagye Benjamin
Аннотация
OBJECTIVES: Ficus capensis (FCE) is widely used in Ghana and some other West African countries to treat gastrointestinal diseases. This study examines the antiulcerogenic properties of the ethanol-based FCE root extract in rats using acetic acid-induced ulcerative colitis model.
METHODS: Rats were arbitrarily assigned to 6 groups (n=5) and given either oral normal saline (10 mL/kg), sulfasalazine (500 mg/kg), or FCE (30, 100, and 300 mg/kg) for 7 days. To induce colitis, 500 μL of acetic acid (4 % v/v) was given intrarectally on day 2. On the 8th day, rats were euthanized. Hematology, antioxidant, and histopathological investigations were assessed.
RESULTS: FCE significantly prevented body weight loss and reduced the colon weight/length ratio to 0.106 ± 0.004 g/cm relative to the control. Additionally, FCE reduced DAI to 2.035 ± 0.1216 compared to the control. The histopathology showed that FCE-treated colons reduced inflammatory scores compared to the control. Levels of NF-κB and TNF-α, gross colonic damage and epithelial cell loss were reduced. FCE elevated colonic SOD and CAT activity to 12.60 ± 1.327 and 9.60 ± 0.6713, correspondingly. Furthermore, the amount of MDA decreased to 29.72 ± 1.974 compared to the control. FCE increased levels of RBC and HGB, respectively, to 8.64 ± 0.48 (×106/µL) and 9.36 ± 0.62 g/dL and lowered WBC and NEU to 10.27 ± 0.36, 9.35 ± 0.62, 20.43 ± 0.82, and 18.47 ± 0.47, respectively, compared to the control.
CONCLUSIONS: Hydroethanolic root extract of FCE possesses antiulcerogenic effects.
METHODS: Rats were arbitrarily assigned to 6 groups (n=5) and given either oral normal saline (10 mL/kg), sulfasalazine (500 mg/kg), or FCE (30, 100, and 300 mg/kg) for 7 days. To induce colitis, 500 μL of acetic acid (4 % v/v) was given intrarectally on day 2. On the 8th day, rats were euthanized. Hematology, antioxidant, and histopathological investigations were assessed.
RESULTS: FCE significantly prevented body weight loss and reduced the colon weight/length ratio to 0.106 ± 0.004 g/cm relative to the control. Additionally, FCE reduced DAI to 2.035 ± 0.1216 compared to the control. The histopathology showed that FCE-treated colons reduced inflammatory scores compared to the control. Levels of NF-κB and TNF-α, gross colonic damage and epithelial cell loss were reduced. FCE elevated colonic SOD and CAT activity to 12.60 ± 1.327 and 9.60 ± 0.6713, correspondingly. Furthermore, the amount of MDA decreased to 29.72 ± 1.974 compared to the control. FCE increased levels of RBC and HGB, respectively, to 8.64 ± 0.48 (×106/µL) and 9.36 ± 0.62 g/dL and lowered WBC and NEU to 10.27 ± 0.36, 9.35 ± 0.62, 20.43 ± 0.82, and 18.47 ± 0.47, respectively, compared to the control.
CONCLUSIONS: Hydroethanolic root extract of FCE possesses antiulcerogenic effects.